报告时间：2015.4.28（星期二）下午16：00
报告地点：博习楼327
报告人：Liang Song 研究员
邀请人：陈新建 特聘教授
报告人简介：Liang Song, Ph.D., is Professor and founding director of the Research Lab for Biomedical Optics and Molecular Imaging at the Shenzhen Institutes of Advanced Technology, the Chinese Academy of Sciences. He also serves as the founding director of the Shenzhen Key Lab for Molecular Imaging. Prior to joining SIAT, he studied at Washington University, St. Louis and received his Ph.D. in Biomedical Engineering in 2010. He has authored more than 30 peer-reviewed journal articles in Biomaterials, Optics Letters, Optics Express etc., which have been cited by prestigious journals including Science and Nature Medicine. His Lab has invented and developed multiple novel photoacoustic imaging technologies, including: (1) optical-resolution intravascular photoacoustic imaging (IVPA) technology, which offers 10-fold resolution improvement over conventional IVPA for interventional guidance of atherosclerosis (PLOS One 2014, 9, e92463; cited by JACC); (2) reflection-mode photoacoustic/two-photon dual-modality in vivo microscopy with a spatial resolution of 320 nm, which can potentially open up new avenues for multi-contrast sub-cellular biomedical imaging(Biomed. Opt. Exp. 2014, 5, 4235; top downloads in both Nov. and Dec., 2014; highlighted by Optical Society of America as Spotlight on Optics); (3) molecular photoacoustic imaging technology and multifunctional molecular probes for cancer theranostics (Theranostics, 2014, 4, 1026).
报告摘要：Photoacoustic imaging has broken through the optical diffusion limit to allow us seeing intact biological tissue in vivo at unprecedented depths (up to several cm) with rich optical contrasts. In addition, photoacoustic imaging can provide anatomic, functional, and molecular information on biological tissue at multiple scales from organelles to organs. Here, we present our development of several acoustic- and optical-resolution photoacoustic microscopy and endoscopy technologies that can offer multi-scale molecular and functional information about intact biological tissue. In particular, three novel photoacoustic imaging technologies developed by our lab will be discussed in detail: (1) in vivo reflection-mode subwavelength resolution photoacoustic/two-photon dual-modality microscopy that offers a spatial resolution as fine as 320 nm and multiple optical contrasts—including absorption, second-harmonic, and fluorescence contrasts; (2) intravascular photoacoustic endomicroscopy with a spatial resolution of 19.6 μm, ~10-fold better over that of conventional intravascular photoacoustics and intravascular ultrasound; and (3) a photoacoustic cancer theranostic platform developed using multi-functional optically triggerable phase-transition molecular nanoprobes. Example applications of these technologies in molecular and functional imaging of cancer and atherosclerotic plaques will also be discussed.